Diagnosis and Treatment of Pleural Cavity Empyema
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Keywords

pleural empyema
diagnostics
drainage of the pleural cavity
pleural puncture
purulent-destructive processes
tuberculosis
telemedicine
antibiotic therapy

How to Cite

Nevzghoda, O. (2025). Diagnosis and Treatment of Pleural Cavity Empyema. SSP Modern Pharmacy and Medicine, 5(3), 93-106. https://doi.org/10.53933/zg1bpe91

Abstract

Pleural empyema remains a serious medical problem, accompanied by a high incidence, a complex clinical course and significant mortality. The article presents the results of a multi-year study of 556 patients who were treated at the Pulmonary Health Center of Lviv in 2017–2024. The clinical forms, etiology, radiological and ultrasound signs of empyema are analyzed, as well as the applied methods of diagnosis and treatment: pleural punctures, drainage, antibiotic therapy, thoracoplasty, decortication. Indications for surgical interventions and features of the course of pleural empyema are given. The importance of early diagnosis, a personalized approach to treatment and prevention of medical errors in the context of the development of telemedicine is emphasized. This large, single-center cohort reflects routine clinical practice in a high-volume referral facility, offering robust, generalizable evidence for settings with constrained resources and rising antimicrobial resistance. By integrating radiologic–sonographic criteria with procedural outcomes, the work clarifies triage, optimizes timing of intervention, and guides antibiotic stewardship, supporting standardized care pathways and telemedicine-enabled follow-up. The findings have immediate implications for guideline refinement, training of multidisciplinary teams, and reduction of complications and length of stay ultimately improving survival, preserving lung function, and enhancing patients’ quality of life. The results obtained may be useful for improving the tactics of managing patients with pleural empyema and reducing the risk of chronicity of the disease.

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References

1. Arnold D., Hamilton F., Morris T. Epidemiology of pleural empyema in English hospitals and the impact of influenza. European Respiratory Journal. 2021. Vol.57. Iss.6. P.: 2003546. DOI: https://doi.org/10.1183/13993003.03546-2020

2. Nielsen J., Meyer Ch., Rosenlund S. Outcome and clinical characteristics in pleural empyema: a retrospective study. Scandinavian Journal of Infectious Diseases. 2011. Vol. 43. Iss. 6-7. P.430-435. DOI: 10.3109/00365548.2011.562527.

3. Shapovalova V. Forensic and Pharmaceutical Risks in the Organization of Pharmacotherapy of Covid, Post-Covid and Long-Covid Disorders. SSP Mod. Pharm. Med. 2022. Vol.2. No.4. P.1-24. URL: https://doi.org/10.53933/sspmpm.v2i4.69

4. Shapovalova V. The ICD-11 for the Twenty-First Century: The First View from the Organizational, Legal, Clinical and Pharmacological Aspects. SSP Mod. Pharm. Med. 2022. Vol.2. No.1. P.1-13. URL: https://doi.org/10.53933/sspmpm.v2i1.37

5. Dellit T., Owens R., McGowan J. et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship. Clin. Infect. Dis. 2007. Vol.44. Iss.2. P.159-177. URL: https://doi.org/10.1086/510393

6. Nemoto K., Yatera K., Akata K. et al. Comparative study of bacterial flora in bronchoalveolar lavage fluid of pneumonia patients based on their pneumonia subtypes and comorbidities using 16S ribosomal RNA gene analysis. Journal of Infection and Chemotherapy. 2022. Vol. 28. No. 10. P. 1402–1409. DOI: https://doi.org/10.1016/j.jiac.2022.06.014.

7. Reheda M.S., Reheda-Furdychko-M.M., Reheda S.M. Furdychko L.O. Pleurisy. Lviv, 2022. 136 p.

8. Feshchenko Y., Kuryk L., Prymushko N. et al. Inhalation risks in the war: chronic lung injury as a result of combat service. Ukr. Pulmonol. J. 2025. Vol.33. No.1. P.5-16. DOI: https://doi.org/10.31215/2306-4927-2025-33-2-5-16

9. Nevzghoda O., Nevzghoda A., Rak L., Kulkova, L. Ultrasound Method for Pleural Punctures in The Diagnosis and Treatment of Exudative Pleuritis. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.2. P.1-11. URL: https://doi.org/10.53933/sspmpm.v4i2.146

10. Nevzghoda O., Nevzghoda A. Thoracoscopy and video-assisted thoracoscopy in diagnostics of pneumothoraxes, traumatic defeats of thorax with pneumothoraxes. SSP Modern Pharmacy and Medicine. 2023. Vol.3. No.4. P.1-10. URL: https://doi.org/10.53933/sspmpm.v3i4.112

11. Nevzghoda O.A., Mortuk Y.V., Maksimovich M.M. Comprehensive treatment of pleural empyema with the use of intrapleural administration of Dioxysol solution. Kharkiv Surgical School. 2004. No. 3. P.34-38.

12. Nevzghoda O. Complications During Transthoracic Lung Biopsies Under the Control of Computer Tomography (Diagnosis of Tumor-Like Formations). SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.1. P.1-10. URL: https://doi.org/10.53933/sspmpm.v4i1.129

13. Chuiev Y., Lavoshnyk O., Shekera O. Recommendations of the World Health Organization on Depressive Disorders in Human Health and Modern Pharmacotherapeutic Approaches to Optimizing Antidepressant Programs in the Alcohol Addiction Clinic. SSP Modern Pharmacy and Medicine. 2025. Vol.5. No.2. P.1-13. URL: https://doi.org/10.53933/sspmpm.v5i2.187

14. Nevzghoda O., Nevzghoda A., Rak L. et al. Thoracic Trauma: Diagnosis and Treatment. SSP Modern Pharmacy and Medicine. 2024. Vol.4. No.3. P.1-14. URL: https://doi.org/10.53933/sspmpm.v4i3.159

15. Nevzghoda O., Nevzghoda A. Modern treatment of inflammatory pulmonary pathology: theoretical justification and implementation of the extracorporeal blood hyperthermia apparatus into medical practice. SSP Modern Pharmacy and Medicine. 2025. Vol.5. No.2. P.1-18. URL: https://doi.org/10.53933/sspmpm.v5i2.189

16. Nevzghoda O., Osyntseva A., Shapovalova V. et al. Optimization of pharmacotherapy for chronic pancreatitis: use of ABC/VED analysis in marketing and pharmacoeconomic studies. Proceedings of Shevchenko Scientific Society Medical Sciences. 2025. Vol. 77. Iss. 1. P. 1-14. DOI: https://doi.org/10.25040/ntsh2025.01.16.

17. Nevzghoda O., Nevzghoda A. Modern treatment of inflammatory pulmonary pathology: theoretical justification and implementation of the extracorporeal blood hyperthermia apparatus into medical practice. SSP Modern Pharmacy and Medicine. 2025. Vol.5. No.2. P.1-18. URL: https://doi.org/10.53933/sspmpm.v5i2.189

18. Nevzghoda O.A., Shapovalov V.V., Shapovalova V.O. et al. Optimisation of antibiotic selection: ABC and VED analysis of medicines against intracellular microorganisms. Tuberculosis, Pulmonary Diseases, HIV-infection. 2025. No. 3 (62). P. 68–79. DOI: http://doi.org/10.30978/TB2025-3-68.

19. Shapovalov V., Shapovalova V., Titarenko I. et al. Chronic Pancreatitis: Pharmacotherapy, Prescription of Drugs, Meta-Analysis, Latest Digital Medical Technologies of Quantum Medicine. Revista Colombiana de Ciencias Químico-Farmacéuticas. 2025. Vol. 54. No. 2. P. 220–244. DOI: https://doi.org/10.15446/rcciquifa.v54n2.117235. URL: https://revistas.unal.edu.co/index.php/rccquifa/article/view/117235

20. Shapovalov V.V., I. Zbrozhek S.I., Shapovalova V.O. et al. Organizational and Legal Evaluation of Availability of Medicines’ Circulation for Cancer Patients. Pharmacia. 2018. Vol.65. No.2. P.17–22. URL: https://bsphs.org/wp-content/uploads/magazine/2018/2/Shapovalov.pdf

21. Shapovalov (Jr.) V., Gudzenko A., Shapovalova V. et al. Forensic and pharmaceutical study of the presence of a causal link between the degree of alcohol abuse and qualification level of the respondents. Pharmacia. 2017. Vol. 64. No. 3. P. 31–39. URL: https://bsphs.org/wp-content/uploads/magazine/2017/3/Shapovalov.pdf

22. Chen L., Chen X., Yu S., Kang M. Innovative operation concept and practice: preoperative precise planning is benefit for lung function protection of early esophageal squamous cell carcinoma by robotic surgical system. Journal of Thoracic Disease. 2020. Vol. 12. No. 5. P. 2728–2729. DOI: https://doi.org/10.21037/jtd.2020.03.116.

23. Duzhy I., Gresko I., Mishchenko Yu. Issues of the epidemiology of pleural empyema. Ukrainian Pulmonological Journal. 2016. No. 3. Supplement. P. 60-62. URL: http://www.ifp.kiev.ua/doc/journals/upj/16_dop/60.pdf

24. World Health Organization. The Selection and Use of Essential Medicines 2023. Executive Summary of the Report of the 24th WHO Expert Committee on Selection and Use of Essential Medicines. WHO. 2023. URL: https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2023.01.

25. European Centre for Disease Prevention and Control. Antimicrobial Consumption in the EU/EEA; ECDC: Stockholm, 2023. URL: https://www.ecdc.europa.eu/en/antimicrobial-consumption.

26. World Health Organization. Global Antimicrobial Resistance and Use Surveillance System (GLASS). WHO. 2023. URL: https://www.who.int/initiatives/glass.

27. European Medicines Agency. Guideline on the Evaluation of Medicinal Products for Bacterial Infections. EMA: London, 2022. URL: https://www.ema.europa.eu.

28. WHO. The WHO AWaRe (Access, Watch, Reserve) antibiotic boo. World Health Organization. 2023. URL: https://www.who.int/publications/i/item/9789240071247.

29. Duodecim Medical Publications Ltd. Guideline 00881. Guidelines on antibacterial therapy. Guidelines based on evidence-based medicine. Ministry of Health of Ukraine. 2017. URL: https://guidelines.moz.gov.ua/documents/3651

30. WHO Collaborating Centre for Drug Statistics Methodology. ATC/DDD Index. 2024. URL: https://atcddd.fhi.no/atc_ddd_index/.

31. Eliopoulos G., Cosgrove S., Carmeli Y. The Impact of Antimicrobial Resistance on Health and Economic Outcomes. Clin. Infect. Dis. 2003. Vol.36. Iss.11. P. 1433–1437. URL: https://doi.org/10.1086/375081.

32. Ventola C. The Antibiotic Resistance Crisis. P&T. 2015. Vol.40. Iss.4. P. 277–283. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378521/.

33. Shapovalova V. Telemedicine and Telepharmacy in Modern Healthcare: Innovations, Medical Technologies, Digital Transformation. SSP Modern Pharmacy and Medicine. 2025. Vol. 5. No. 3. P. 1–19. DOI: https://doi.org/10.53933/r7f5xj91

34. Shapovalov V. Multidisciplinary study of medical errors in the system of legal relations between "Doctor-Patient-Pharmacist-Advocate" during the circulation of drugs. SSP Modern Pharmacy and Medicine. 2023. Vol. 3. No. 2. P. 1–11. DOI: https://doi.org/10.53933/sspmpm.v3i2.88

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Copyright (c) 2025 Oleksandr Nevzghoda (Author)